0000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 0000002 - Statement - Condensed Consolidated Balance Sheets (Unaudited) link:presentationLink link:calculationLink link:definitionLink 0000003 - Statement - Condensed Consolidated Balance Sheets (Unaudited) (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 0000004 - Statement - Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) link:presentationLink link:calculationLink link:definitionLink 0000005 - Statement - Condensed Consolidated Statement of Stockholders’ Equity (Unaudited) link:presentationLink link:calculationLink link:definitionLink 0000006 - Statement - Condensed Consolidated Statements of Cash Flow (Unaudited) link:presentationLink link:calculationLink link:definitionLink 0000007 - Disclosure - Nature of business and future operations link:presentationLink link:calculationLink link:definitionLink 0000008 - Disclosure - Significant accounting policies link:presentationLink link:calculationLink link:definitionLink 0000009 - Disclosure - Fair value measurements link:presentationLink link:calculationLink link:definitionLink 0000010 - Disclosure - Investments in marketable securities link:presentationLink link:calculationLink link:definitionLink 0000011 - Disclosure - Investment in Genevant link:presentationLink link:calculationLink link:definitionLink 0000012 - Disclosure - Accounts payable and accrued liabilities link:presentationLink link:calculationLink link:definitionLink 0000013 - Disclosure - Sale of future royalties link:presentationLink link:calculationLink link:definitionLink 0000014 - Disclosure - Contingencies and commitments link:presentationLink link:calculationLink link:definitionLink 0000015 - Disclosure - Collaborations, contracts and licensing agreements link:presentationLink link:calculationLink link:definitionLink 0000016 - Disclosure - Shareholders’ equity link:presentationLink link:calculationLink link:definitionLink 0000017 - Disclosure - Subsequent Events link:presentationLink link:calculationLink link:definitionLink 9954471 - Disclosure - Significant accounting policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9954472 - Disclosure - Fair Value Measures and Disclosures (Policies) link:presentationLink link:calculationLink link:definitionLink 9954473 - Disclosure - Fair value measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 9954474 - Disclosure - Investments in marketable securities (Tables) link:presentationLink link:calculationLink link:definitionLink 9954475 - Disclosure - Accounts payable and accrued liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 9954476 - Disclosure - Sale of future royalties (Tables) link:presentationLink link:calculationLink link:definitionLink 9954477 - Disclosure - Collaborations, contracts and licensing agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 9954478 - Disclosure - Shareholders’ equity (Tables) link:presentationLink link:calculationLink link:definitionLink 9954479 - Disclosure - Nature of business and future operations (Details) link:presentationLink link:calculationLink link:definitionLink 9954480 - Disclosure - Significant accounting policies (Details) link:presentationLink link:calculationLink link:definitionLink 9954481 - Disclosure - Fair value measurements - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9954482 - Disclosure - Fair value measurements - Assets and Liabilities Measured at Fair Value on Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9954483 - Disclosure - Fair value measurements - Changes in Fair Value of Contingent Consideration (Details) link:presentationLink link:calculationLink link:definitionLink 9954484 - Disclosure - Investments in marketable securities - Marketable Securities (Details) link:presentationLink link:calculationLink link:definitionLink 9954485 - Disclosure - Investments in marketable securities - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9954486 - Disclosure - Investment in Genevant (Details) link:presentationLink link:calculationLink link:definitionLink 9954487 - Disclosure - Accounts payable and accrued liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9954488 - Disclosure - Sale of future royalties - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9954489 - Disclosure - Sale of future royalties - Liability Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9954490 - Disclosure - Contingencies and commitments (Details) link:presentationLink link:calculationLink link:definitionLink 9954491 - Disclosure - Collaborations, contracts and licensing agreements (Details) link:presentationLink link:calculationLink link:definitionLink 9954492 - Disclosure - Shareholders’ equity - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9954493 - Disclosure - Shareholders’ equity - Stock-based Compensation (Details) link:presentationLink link:calculationLink link:definitionLink 9954494 - Disclosure - Subsequent Events (Details) link:presentationLink link:calculationLink link:definitionLink