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Disclosure - Significant accounting policies (Policies) link:presentationLink link:calculationLink link:definitionLink 2404401 - Disclosure - Significant accounting policies (Details) link:presentationLink link:calculationLink link:definitionLink 2105103 - Disclosure - Fair value of financial instruments link:presentationLink link:calculationLink link:definitionLink 2306301 - Disclosure - Fair value of financial instruments (Tables) link:presentationLink link:calculationLink link:definitionLink 2407402 - Disclosure - Fair value of financial instruments - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 2408403 - Disclosure - Fair value of financial instruments - Assets and Liabilities Measured at Fair Value on Recurring Basis (Details) link:presentationLink link:calculationLink link:definitionLink 2409404 - Disclosure - Fair value of financial instruments - Changes in Fair Value of Liabilities-Classified as Stock Option (Details) link:presentationLink link:calculationLink link:definitionLink 2410405 - Disclosure - Fair value of financial instruments - Changes in Fair Value of Contingent Consideration (Details) link:presentationLink link:calculationLink link:definitionLink 2111104 - Disclosure - Investments in marketable securities link:presentationLink link:calculationLink link:definitionLink 2312302 - Disclosure - Investments in marketable securities (Tables) link:presentationLink link:calculationLink link:definitionLink 2413406 - Disclosure - Investments in marketable securities- Marketable Securities (Details) link:presentationLink link:calculationLink link:definitionLink 2414407 - Disclosure - Investments in marketable securities - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 2115105 - Disclosure - Equity method investment link:presentationLink link:calculationLink link:definitionLink 2416408 - Disclosure - Equity method investment (Details) link:presentationLink link:calculationLink link:definitionLink 2117106 - Disclosure - Accounts payable and accrued liabilities link:presentationLink link:calculationLink link:definitionLink 2318303 - 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Disclosure - Collaborations, contracts and licensing agreements link:presentationLink link:calculationLink link:definitionLink 2327305 - Disclosure - Collaborations, contracts and licensing agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 2428413 - Disclosure - Collaborations, contracts and licensing agreements (Details) link:presentationLink link:calculationLink link:definitionLink 2129110 - Disclosure - Stockholders’ equity link:presentationLink link:calculationLink link:definitionLink 2330306 - Disclosure - Stockholders’ equity (Tables) link:presentationLink link:calculationLink link:definitionLink 2431414 - Disclosure - Stockholders’ equity - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 2432415 - Disclosure - Stockholders’ equity - Stock-based Compensation (Details) link:presentationLink link:calculationLink link:definitionLink 2133111 - Disclosure - Related Party Transactions link:presentationLink link:calculationLink link:definitionLink 2434416 - Disclosure - Related Party Transactions (Details) link:presentationLink link:calculationLink link:definitionLink