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Arbutus Biopharma Corporation
701 Veterans Circle
Warminster, Pennsylvania 18974

January 8, 2020

VIA EDGAR

U.S. Securities and Exchange Commission
Division of Corporation Finance
100 F Street, N.E.
Washington, D.C. 20549

    
Re:    Arbutus Biopharma Corporation
Registration Statement on Form S-3
Filed December 23, 2019
File No. 333-235674
Request for Acceleration of Effective Date
                
Ladies and Gentlemen:
Pursuant to Rule 461 of the General Rules and Regulations under the Securities Act of 1933, as amended, Arbutus Biopharma Corporation hereby requests that the Securities and Exchange Commission take appropriate action to cause the above-referenced Registration Statement on Form S-3 (the “Registration Statement”) to become effective on January 10, 2020, at 4:00 p.m. Eastern Standard Time, or as soon thereafter as is practicable.
Once the Registration Statement has been declared effective, please orally confirm that event with Steve Abrams of Hogan Lovells US LLP at (267) 675-4671.

ARBUTUS BIOPHARMA CORPORATION


By:     /s/ David C. Hastings                
Name:     David C. Hastings
Title:
Chief Financial Officer