Dr. Murray has served as Arbutus’ President, Chief Executive Officer and Director since May 2008, when Dr. Murray joined Arbutus in connection with the closing of the business combination between Arbutus and Protiva. He previously was the President and CEO and founder of Protiva since its inception in the summer of 2000. Dr. Murray has over 20 years of experience in both the R&D and business development and management facets of the biotechnology industry. Dr. Murray has held senior management positions at ZymoGenetics and Xcyte Therapies prior to joining Protiva. Since entering the biotechnology industry Dr. Murray has successfully completed numerous and varied partnering deals, directed successful product development programs, been responsible for strategic planning programs, raised over $30 million in venture capital and executed extensive business development initiatives in the U.S., Europe and Asia. During his R&D career, Dr. Murray worked extensively on three programs that resulted in FDA approved drugs, including the first growth factor protein approved for human use, a program he led for several years following his discovery. Dr. Murray obtained his Ph.D. in Biochemistry from the University of Oregon Health Sciences University and was a Damon Runyon-Walter Winchell post-doctoral research fellow for three years at the Massachusetts Institute of Technology.
Mr. Bruce Cousins joined Arbutus as Executive Vice President and Chief Financial Officer in October 2013. Mr. Cousins brings to Arbutus extensive global financial and pharmaceutical industry experience both working for multi-million dollar companies and leading start-ups through to successful completion of their strategic growth plans. In 2004, Mr. Cousins joined Aspreva Pharmaceuticals and led its highly successful IPO. In 2008, he played a key leadership role in the eventual sale of Aspreva in a $915 million all-cash transaction. Prior to joining Aspreva, Mr. Cousins spent 14 years with Johnson & Johnson (J&J) working in operations and finance, both domestically and internationally. Prior to the pharmaceutical industry, Mr. Cousins was a chartered accountant with Deloitte & Touche. More recently, Mr. Cousins has spent the past few years in the renewable energy sector, and from 2011 to 2013 he was Chief Executive Officer of Carmanah Technologies Corporation, a TSX-listed company. Prior to Carmanah, he held Chief Financial Officer positions at Xantrex Technology Inc. and Ballard Power Systems. Mr. Cousins completed a Bachelor of Commerce degree from McMaster University in 1987 and received a Chartered Accountant designation in 1989.
Dr. Elizabeth Howard serves as our Executive Vice President and General Counsel. Dr. Howard has been practicing law for more than 20 years. Prior to joining Arbutus in March 2015, she was an intellectual property partner at Orrick, where she co-chaired Orrick's life sciences practice focusing on patent infringement litigation. Her practice also included trade secrets disputes and handling anti-counterfeiting matters in the pharmaceutical industry. In addition to litigating in numerous federal district courts and California state courts, Dr. Howard has appeared before the U.S. Patent and Trademark Office in interference proceedings, arbitrated before numerous tribunals, and litigated before the U.S. International Trade Commission (ITC). Dr. Howard also served as a deputy district attorney in the county of Santa Clara. Additionally, Dr. Howard counseled clients in negotiation and drafting of agreements in licensing or other technology transactions. She also speaks and publishes regularly on intellectual property matters affecting the life sciences industry. Dr. Howard has been listed as a "leading lawyer" in “PLC Which Lawyer" for her litigation successes in life sciences, and named to the Daily Journal's list of "Top 75 IP Litigators in California" in 2013. Before law school, Dr. Howard was an NSF Plant Molecular Biology Postdoctoral Fellow at the CSIRO Division of Plant Industry in Canberra, Australia, and a Research Geneticist at the University of California, Berkeley. Dr. Howard obtained her doctorate with Dr. Elizabeth Blackburn (2009 Nobel Laureate, Physiology or Medicine). Dr. Howard holds a B.A. with honors from the University of California, Santa Barbara, a Ph.D. in Molecular Biology from the University of California, Berkeley, a J.D. from the University of California, Hastings College of the Law, and is a member of the United States Patent Bar
Mr. Patrick Higgins serves as Arbutus’ Chief Business Officer. Mr. Higgins was a co-founder of OnCore Biopharma and served as a member of its board of directors since its inception in May 2012 and as its Chief Executive Officer since July 2014. Mr. Higgins previously served as Executive Vice-President, Marketing and Sales of Pharmasset, Inc., a specialty pharmaceutical company, from 2007 to January 2012 and was a consultant to Pharmasset from 2006 to 2007. From 1995 to 2006, Mr. Higgins was the Vice-President, Sales and Marketing, Virology at Hoffmann-LaRoche, a pharmaceutical company. Mr. Higgins received his B.A. degree from Villanova University and his M.B.A. degree from Seton Hall University.
Dr. Sofia was one of OnCore Biopharma’s co-founders and served as its Chief Scientific Officer and Head of Research and Development since July 2014. He previously served as President and a member of its board of directors from May 2012 to August 2014. Since April 2012, Dr. Sofia has been a professor at the Baruch S. Blumberg Institute and since March 2013, Dr. Sofia has been an adjunct professor at the Drexel University School of Medicine. Previously, Dr. Sofia was the Senior Vice-President, Chemistry, Site Head and then Senior Advisor at Gilead Sciences, Inc. from January 2012 to December 2012. Prior to that, Dr. Sofia was the Senior Vice-President, Chemistry at Pharmasset, Inc. from August 2005 to January 2012. From 1999 to 2005, Dr. Sofia served as a Group Director, New Leads Chemistry at Bristol-Myers Squibb. From 1993 to 1999, Dr. Sofia established and directed the research programs at Transcell Technologies, first as Director of Chemistry and then as Vice-President of Research. Dr. Sofia received his B.A. degree from Cornell University, his Ph.D. degree from the University of Illinois at Urbana-Champaign and was an NIH postdoctoral fellow at Columbia University. Dr. Sofia has won the Economist’s 2015 Innovation Award in the Bioscience category, for developing a rapid cure for hepatitis C virus infection (HCV).
Dr. Mark Kowalski has served as our Chief Medical Officer since August 2013. Dr. Kowalski has extensive experience in Phase I through Phase IV drug development and clinical trials in a wide variety of therapeutic areas including oncology, urology, infectious diseases, analgesia, allergy, rheumatology and cardiovascular diseases. His experience also includes basic scientific research on the molecular biology of HIV as well as clinical practice in internal medicine. Prior to joining Arbutus, Dr. Kowalski worked in the oncology and inflammation therapeutic area at Gilead Sciences, Inc. following Gilead’s $510-million acquisition of YM BioSciences Inc. Previously, Dr. Kowalski had been CMO and Vice President of Regulatory Affairs at YM BioSciences Inc. Dr. Kowalski’s experience also encompasses being the CMO and Vice President of Medical/Regulatory Affairs at Viventia Biotechnologies Inc. Prior to Viventia, he was the Senior Director of Medical Affairs at AAIPharma Inc. Dr. Kowalski holds a B.A. from Rutgers University and an M.D. and Ph.D. from the University of Kansas School of Medicine. He completed his postgraduate training in internal medicine and infectious diseases at Duke University and Harvard Medical School.
Dr. Peter Lutwyche serves as Arbutus’ Chief Technology Officer. Dr. Lutwyche’s responsibilities at Arbutus include manufacturing, process development and quality control for all Arbutus product candidates, as well as supporting Arbutus' collaborative partners as they advance products that utilize Arbutus's technology. Previously Dr. Lutwyche was Director, Pharmaceutical Development at QLT Inc. During his tenure at QLT, Dr. Lutwyche contributed to the development and commercialization of Visudyne as well as leading manufacturing and chemistry efforts for numerous pre-clinical and clinical stage products. Prior to QLT, he was a research scientist at Inex Pharmaceuticals Corporation working with lipid-based formulations of nucleic acids and antibiotics. Dr. Lutwyche holds a Ph.D. in Chemistry from the University of British Columbia.
Dr. Symonds served as a director of OnCore since August 2014 and as a Senior Advisor since November 2014. Dr. Symonds is currently Senior Vice President, Clinical Research at Roivant Sciences, Inc., a position he has held since May 2014. Prior to that, Dr. Symonds served as Vice-President, Liver Disease Therapeutic Area at Gilead Sciences, Inc. from February 2012 until April 2014, and was the Senior Vice-President, Clinical Pharmacology and Translational Medicine at Pharmasset, Inc. from 2007 to January 2012. From 1993 to 2007, Dr. Symonds held various positions of increasing responsibility at GlaxoSmithKline, most recently as Director, Antiviral Clinical Pharmacology and Discovery Medicine. Dr. Symonds received his Doctor of Pharmacy degree from Campbell University and completed a fellowship in clinical pharmacokinetics at the Clinical Pharmacokinetics Laboratory in Buffalo, New York.
Dr. Michael Abrams serves as the Managing Director of the business unit dedicated to Arbutus' non-HBV assets. Prior to joining Arbutus, Dr. Abrams was Chief Innovation Officer and VP, Research and Development at CDRD Ventures Inc. Previously, Dr Abrams was President and CEO of Inimex. He was the founding CEO of AnorMED, Inc. and led that company as President and CEO for ten years. AnorMED discovered and developed Mozobil, a drug for improving stem cell mobilization for patients undergoing stem cell transplantation. Mozobil was approved by the FDA in 2008 and AnorMED was acquired by Genzyme Corp. in 2006 for $580M. Prior to AnorMED, Dr. Abrams was Manager Biomedical Research for Johnson Matthey, plc where he led the spin-off of the biomedical research group to form AnorMED. From 2009 to 2013, Dr. Abrams served as Board Chairman of Indel Therapeutics. Dr. Abrams has a Ph.D. in Chemistry from the Massachusetts Institute of Technology and a BA in Chemistry from Bowdoin College. In 2009 he was a corecipient of the Georg Charles de Hevesy Nuclear Pioneer Award from the Society of Nuclear Medicine for his work in the invention of the radiopharmaceutical, Cardiolite.
Dr. Di Bisceglie received his medical degree from the University of Witwatersrand, Johannesburg, South Africa in 1977 and completed his training in Internal Medicine at Baragwanath Hospital, Johannesburg (1981-1984) before doing his research fellowship at the National Institutes of Health (NIH) between 1986 and 1988. He went on to become a Senior Investigator, and then chief of the Liver Diseases Section, NIDDK. Dr. Di Bisceglie joined the faculty of Saint Louis University School of Medicine as Professor of Internal Medicine in 1994. Dr. Di Bisceglie is an internationally recognized expert in the field of viral hepatitis and liver disease and has published over 300 peer reviewed publications and has served on the editorial boards of many journals including Hepatology, Liver Transplantation and as Section Editor, Hepatitis C for UpToDate. He has served on many international and national committees including the Scientific Planning Committee for the 13th International Symposium on Viral Hepatitis and Liver Disease (2009), and has chaired the AASLD Public Policy and Clinical Research Committees. He was recently appointed to the Governing Board of AASLD. At the Food and Drug Administration he served as a member on the Blood Products Advisory Committee. He also serves as a member of the U.S. Hepatitis Panel for the U.S. Japan Cooperative Medical Sciences Program. Dr. Di Bisceglie has received numerous honors and awards, including the Fiterman Foundation Clinical Research in Hepatology or Nutrition (Hugh R. Butt) Award. He is currently is PI and Co-PI on several NIH sponsored grants and served as Chair, Steering Committee for the HALT-C Trial group from 1999-2011. At Saint Louis University, Dr. Di Bisceglie initially served as Associate Chairman for Education and residency program director (1994-1999). He has served on multiple institutional committees, including Curriculum Oversight Committee, the Governing Board of Saint Louis University Hospital (1998-2000) and more recently the Governing Board of the University Medical group. He was appointed as acting chairman of the Department of Internal Medicine in 2006 and then as chairman in May 2009.
Dr. Rice is the Maurice R. and Corinne P. Greenberg Chair in Virology and serves as Head of the Laboratory for Virology and Infectious Disease at Rockefeller University. He is one of the world’s most accomplished virologists and a prominent figure in research on members of the Flaviviridae including hepatitis C virus (HCV). Dr. Rice received his bachelor’s degree from University of California Davis in 1974 and earned his Ph.D. from California Institute of Technology in 1981. From 1986-2000, Dr. Rice was a faculty member at Washington University in St. Louis. His research team has helped to understand the biogenesis and structure of HCV-encoded proteins, discovered a highly conserved RNA element at the 3’ terminus of HCV genome RNA, and produced the first infectious molecular clone of the virus—an essential tool for future studies on this important human pathogen. His laboratory has established cell culture systems and animal models for studying HCV replication and evaluating antiviral efficacy. Dr. Rice has co-authored over 400 articles in the field of virology, serves as a reviewer for numerous journals, is a former editor of Journal of Virology, is a past President of the American Society for Virology, a Fellow of the American Association for the Advancement of Science, and a Member of the National Academy of Sciences. For more specific information about Dr. Rice’s research, please go to http://www.hepccenter.org.
Dr. Biller joined Agios Pharmaceuticals as Chief Scientific Officer in September of 2010. Agios, a biotech in Cambridge, Massachusetts, is focused on the discovery of novel antitumor therapeutics that capitalize on the metabolic dysregulation of cancer cells, as well as the discovery of therapies for rare genetic disorders of metabolism. Over the past five years, Agios has discovered five first in class investigational medicines, two of which have demonstrated clinical activity in acute myeloid leukemia. Prior to Agios, he was Vice President and Head of Global Discovery Chemistry at the Novartis Institutes for BioMedical Research. He was responsible for the world-wide chemistry functions at Novartis, including medicinal, combinatorial and computational chemistry, as well as discovery metabolism and pharmacokinetics. Prior to Novartis, Scott was Vice President, Pharmaceutical Candidate Optimization and Executive Director of Metabolic Diseases Chemistry at the Bristol-Myers Squibb Pharmaceutical Research Institute. Under his leadership, the Metabolic Diseases Area discovered multiple investigational medicines, leading to three marketed drugs: the DPP4 inhibitor Onglyza™ for Type 2 diabetes, the SGLT2 inhibitor Forxiga™ for Type 2 diabetes and the MTP inhibitor Juxtapid™ for familial hypercholesterolemia. The latter two molecules are first in class in their category. Scott was awarded the 2014 American Chemical Society’s Heroes of Chemistry Award for the discovery of Juxtapid™. Scott gained his SB degree at the Massachusetts Institute of Technology in 1976 and his PhD in Organic Chemistry in 1982 at the California Institute of Technology. He held an NIH Postdoctoral Fellowship in natural product synthesis at Columbia University (1982-1983). He has co-authored over 100 patents and publications.
Dr. Protzer obtained her M.D. in at the University of Erlangen in 1988, and completed her training in Internal Medicine with a focus on Liver and Infectious Diseases in Frankfurt and at the University Hospital Mainz in 1996. She then completed a training in Medical Microbiology and Virology at the University Hospitals in Heidelberg and Cologne in 2005. She was a postdoctoral fellow at the Center for Molecular Biology Heidelberg, where her research focused on “Virus-Host Interaction of Hepatitis B Virus”, started her independent research group at the University of Heidelberg in 2000, and led the Molecular Infectiology group at the University of Cologne, Institute for Medical Microbiology, Immunology and Hygiene from 2002 - 2007. In 2007, she was a professor and Chair in Virology, Technical University of Munich (TUM), and has since served as the Director of Virology at Helmholtz Zentrum München and TUM. Dr. Protzer serves as a vice speaker and a member of the executive board of the German Center for Infection Research since 2011, and has been on different advisory boards e.g. of the German Ministry of Education and Research, University of Regensburg und University Hospital Cologne. Her memberships include the German Center for Infection Research (DZIF), European Association for the Study of the Liver (EASL), German Association for the Study of the Liver (GASL), Society of Virology, the German Society for Gene Therapy, and the Global Virus Network. Dr. Protzer has published more than 120 articles.
Dr. Zoulim obtained his M.D. in Gastroenterology and Hepatology in Lyon Medical School in 1991. He has also obtained a PhD in Molecular and Cellular Biology and was trained as a post-doctoral researcher at Fox Chase Cancer Center in Philadelphia. He is Professor of Medicine at Lyon I University since 1997. He is currently Medical Director of the Hepatology Department at the Hospices Civils de Lyon, and Scientific Director of the Department of Immunology and Virology of INSERM Unit 1052 where he is leading the team on ‘Antiviral therapy of viral hepatitis’. Dr Zoulim has served as an Associate Editor for Journal of Hepatology and is currently Associate Editor for Gut. He also served as an expert in the microbiology study section of the INSERM and is currently head of the clinical viral hepatitis study section at ANRS. He served as a Governing Board member of the European Association for the Study of the Liver (EASL). Dr Zoulim received the William Prusoff award of the International Society for Antiviral Research. Furthermore, he has been the scientific coordinator of a European community-funded Network of Excellence on the management of antiviral drug resistance, and is currently head of the ANRS “HBV cure” program in France. Fabien Zoulim is a recognized expert in the field of viral hepatitis and antiviral therapy. He has published more than 350 articles (H index 62, Web of Science).